Pitx2^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm1Hmd
• Name: paired-like homeodomain transcription factor 2; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:3767234
• Synonyms: Pitx2^deltaASE
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J X (C57BL/6 x C3H)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The 0.6 kb intronic enhancer (ASE) region was replaced with a neo cassette that was subsequently removed by cre-mediated recombination following electroporation of a CAG-cre vector. Deletion was confirmed by PCR. (J:128475)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 39 strains or lines available

References

• Original: J:128475 Shiratori H, et al., Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 2006 Aug;133(15):3015-25
• All: 7 reference(s)