Tlr7^rsq1
Chemically induced Allele Detail

Summary

• Symbol: Tlr7^rsq1
• Name: toll-like receptor 7; resiquimod unresponsive 1
• MGI ID: MGI:3767244
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^rsq1 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The rsq1 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is a C-to-T transition at nucleotide position 391 of the gene (Genbank Accession NM_133211) resulting in replacement of threonine by isoleucine at amino acid position 68, in the first leucine-rich repeat (LRR) of the receptor. (J:128404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 20 strains or lines available

Notes

This mutation was identified in a hemizygous male mouse.

References

• Original: J:128404 Beutler B, et al., An ENU-induced point mutation of Tlr7 specifically ablates immune response to resiquimod. MGI Direct Data Submission. 2007
• All: 4 reference(s)