Tcra-J^tm3.1Krg
Targeted Allele Detail

Summary

• Symbol: Tcra-J^tm3.1Krg
• Name: T cell receptor alpha, joining region; targeted mutation 3.1, Michael S Krangel
• MGI ID: MGI:3767247
• Synonyms: Tcra-J^tm3Krg, Tcra^tm3Krg, TEA-T
• Gene: Tcra-J Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128344
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A transcriptional terminator and a loxP site flanked neomycin resistance gene cassette were inserted downstream of the TEA (T early alpha) exon. The neo cassette was subsequently removed by cre-mediated recombination. (J:128344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcra-J Mutation: 0 strains or lines available

References

• Original: J:128344 Abarrategui I, et al., Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J. 2007 Oct 17;26(20):4380-90
• All: 4 reference(s)