Cdkn2b^tm2Brn
Targeted Allele Detail

Summary

• Symbol: Cdkn2b^tm2Brn
• Name: cyclin dependent kinase inhibitor 2B; targeted mutation 2, Anton Berns
• MGI ID: MGI:3767459
• Synonyms: Ink4ab^-
• Gene: Cdkn2b Location: Chr4:89224536-89229276 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2b^tm2Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125189
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a PGK-hyg cassette with a 5' loxP site in ES cells containing the Cdkn2a^tm1.1Brn. Integration occurred on the chromosome that contained the wild-type Cdkn2a^tm1.1Brn allele. The absence of the p15^Ink4b and p16^Ink4a protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2b^tm2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2b Mutation: 7 strains or lines available

References

• Original: J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
• All: 5 reference(s)