Del(4Cdkn2a-Cdkn2b)2Brn
Targeted Allele Detail

Summary

• Symbol: Del(4Cdkn2a-Cdkn2b)2Brn
• Name: deletion, Chr 4, Anton Berns 2
• MGI ID: MGI:3767464
• Synonyms: Cdkn2ab^-, Cdkn2a/Cdkn2b^tm2Brn, Cdkn2a/Cdkn2b^tm2Nki, Del2Brn
• Gene: Del(4Cdkn2a-Cdkn2b)2Brn Location: unknown Genetic Position: Chr4, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125189
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(4Cdkn2a-Cdkn2b)2Brn involves 2 genes/genome features (Cdkn2a, Cdkn2b) View all
• Mutation details: Germ line cre mediated recombination between the loxP site in Cdkn2b^tm2Brn and the loxP site in Cdkn2a^tm1.1Brn deleted a genomic segment encompassing the promoter of Cdkn2b and intron 2 of the Cdkn2a exon 1a. The absence of p15^Ink4b, p16^Ink4a and p19^Arf protein products was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:125189)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Del(4Cdkn2a-Cdkn2b)2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(4Cdkn2a-Cdkn2b)2Brn Mutation: 0 strains or lines available

Notes

ES cells used possessed the Cdkn2a^tm1.1Brn and Cdkn2b^tm2Brn alleles on the same chromosome.

References

• Original: J:125189 Krimpenfort P, et al., p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature. 2007 Aug 23;448(7156):943-6
• All: 2 reference(s)