Bco1^tm1Dnp
Targeted Allele Detail

Summary

• Symbol: Bco1^tm1Dnp
• Name: beta-carotene oxygenase 1; targeted mutation 1, Adrian Wyss
• MGI ID: MGI:3767552
• Synonyms: CMO1^-, CMO1^tm1dnp
• Gene: Bco1 Location: Chr8:117822593-117860459 bp, + strand Genetic Position: Chr8, 63.61 cM, cytoband E1
• Alliance: Bco1^tm1Dnp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128383
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene and floxed neo cassette replaced an 8.8 kb fragment including half of exon 2 and exon 3. Immunoblot analysis of homozygous livers confirmed absence of protein expression. (J:128383)

Expression

In Mice Carrying this Mutation:	29 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bco1 Mutation: 32 strains or lines available

References

• Original: J:128383 Hessel S, et al., CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice. J Biol Chem. 2007 Nov 16;282(46):33553-61
• All: 27 reference(s)