Tenm3^tm1Cal
Targeted Allele Detail

Summary

• Symbol: Tenm3^tm1Cal
• Name: teneurin transmembrane protein 3; targeted mutation 1, Catherine A Leamey
• MGI ID: MGI:3767554
• Synonyms: Ten3^delta4, Ten_m3 KO
• Gene: Tenm3 Location: Chr8:48680717-49296986 bp, - strand Genetic Position: Chr8, 27.02 cM, cytoband B2
• Alliance: Tenm3^tm1Cal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128389
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4, encoding the trans-membrane domain was disrupted by the insertion of a neomycin cassette. Quantitative PCR analysis indicated that transcript expression was significantly reduced in homozygous mice. Western blot analysis confirmed the absence of protein in brain lysates from homozygous mice. (J:128389)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tenm3 Mutation: 225 strains or lines available

References

• Original: J:128389 Leamey CA, et al., Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision. PLoS Biol. 2007 Sep;5(9):e241
• All: 11 reference(s)