Tlr9^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^M2Btlr
• Name: toll-like receptor 9; mutation 2, Bruce Beutler
• MGI ID: MGI:3767565
• Synonyms: CpG2, Tlr9^CpG2, unmethylated CpG-oligodeoxynucleotide unresponsive 2
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The Cpg2 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 3060 of the gene (Genbank Accession NM_031178) that results replacement of glutamine by leucine at amino acid position 985 of the receptor protein. (J:128405)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

References

• Original: J:128405 Xiao N, et al., A second ENU-induced point mutation of Tlr9 specifically ablates immune response to oligodeoxynucleotides containing unmethylated CpG motifs. MGI Direct Data Submission. 2007
• All: 1 reference(s)