Tlr9^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^m3Btlr
• Name: toll-like receptor 9; mutation 3, Bruce Beutler
• MGI ID: MGI:3767571
• Synonyms: Cpg3, Tlr9^CpG3, unmethylated CpG-oligodeoxynucleotide unresponsive 3
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The Cpg3 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is a T-to-A transversion at nucleotide position 747 of the gene (Genbank Accession NM_031178) that results in replacement of valine by glutamic acid at amino acid position 214 of the receptor protein. (J:128406)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 66 strains or lines available

Notes

The inheritance of the phenotype associated with this mutation is likely semidominant, as are other mutations at this locus, but heterozygous mutant mice have not been characterized. (J:128406)

References

• Original: J:128406 Berger M, et al., A third ENU-induced point mutation of Tlr9 specifically ablates immune response to oligodeoxynucleotides containing unmethylated CpG motifs. MGI Direct Data Submission. 2007
• All: 3 reference(s)