Tlr4^lps-Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr4^lps-Btlr
• Name: toll-like receptor 4; defective lipopolysaccharide response Bruce Beutler
• MGI ID: MGI:3767575
• Synonyms: lps3, Tlr4^lps3, defective lipopolysaccharide response 3
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^lps-Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The lps3 phenotype was identified in an ENU mutagenesis screen for mutants with impaired response to Toll-like receptor (TLR) ligands. The mutation is an A-to-T transversion at nucleotide position 2147 of the gene (Genbank Accession NM_021297) that results in replacement of aspartic acid by valine at amino acid position 709 of the receptor protein. (J:128416)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 91 strains or lines available

References

• Original: J:128416 Siggs O, et al., An ENU-induced point mutation of Tlr4 ablates immune response to LPS. MGI Direct Data Submission. 2007
• All: 2 reference(s)