Fbxw7^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1Kei
• Name: F-box and WD-40 domain protein 7; targeted mutation 1, Keiichi Nakayama
• MGI ID: MGI:3767577
• Synonyms: Fbxw7^F
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128523
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 5 with an additional loxP site inserted downstream of exon 5. Cre-mediated recombination using a transiently transfected pMC-Cre vector was used to remove the neo cassette. (J:128523)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fbxw7^tm1Kei

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:128523 Onoyama I, et al., Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med. 2007 Nov 26;204(12):2875-88
• All: 17 reference(s)