Fbxw7^tm1.1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1.1Kei
• Name: F-box and WD-40 domain protein 7; targeted mutation 1.1, Keiichi Nakayama
• MGI ID: MGI:3767578
• Synonyms: Fbxw7^deltaE5
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1.1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128523
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Germline cre-mediated recombination was used to remove the floxed exon 5. (J:128523)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:128523 Onoyama I, et al., Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med. 2007 Nov 26;204(12):2875-88
• All: 2 reference(s)