Tgfbr1^tm1Mulm
Targeted Allele Detail

Summary

• Symbol: Tgfbr1^tm1Mulm
• Name: transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery
• MGI ID: MGI:3767608
• Synonyms: ALK5^KI
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^tm1Mulm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128498
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Single point mutation
• Mutation details: The coding region was replaced with one containing a A to C substitution in exon 4 resulting in the substitution of alanine for aspartic acid at position 266 (D266A). This mutation prevents SMAD2 and SMAD3 activation but does not affect interacts with Acvrl1. RT-PCR analysis on spleen and liver was used to confirm the expression of the modified transcript. (J:128498)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

References

• Original: J:128498 Carvalho RL, et al., Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice. J Cell Sci. 2007 Dec 15;120(Pt 24):4269-77
• All: 2 reference(s)