Bcl11b^tm1Avram
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm1Avram
• Name: B cell leukemia/lymphoma 11B; targeted mutation 1, Dorina Avram
• MGI ID: MGI:3767620
• Synonyms: BCL11B^F
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm1Avram page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3, which includes most of the gene's coding sequence, was flanked by LoxP sites. (J:128515)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 46 strains or lines available

References

• Original: J:128515 Albu DI, et al., BCL11B is required for positive selection and survival of double-positive thymocytes. J Exp Med. 2007 Nov 26;204(12):3003-15
• All: 10 reference(s)