Sort1^tm1Tew
Targeted Allele Detail

Summary

• Symbol: Sort1^tm1Tew
• Name: sortilin 1; targeted mutation 1, Thomas E Willnow
• MGI ID: MGI:3767625
• Synonyms: Sort1^-
• Gene: Sort1 Location: Chr3:108191398-108268827 bp, + strand Genetic Position: Chr3, 46.9 cM, cytoband F3
• Alliance: Sort1^tm1Tew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128451
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/SvEmcTer

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 126 bp of exon 14 and 202 bp of the subsequent intron were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis and immunohistochemistry. (J:128451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sort1 Mutation: 49 strains or lines available

Notes

ES cell line = ICp4.

References

• Original: J:128451 Jansen P, et al., Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci. 2007 Nov;10(11):1449-57
• All: 20 reference(s)