Bub1^tm1Ssta
Targeted Allele Detail

Summary

• Symbol: Bub1^tm1Ssta
• Name: BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Stephen S Taylor
• MGI ID: MGI:3767632
• Synonyms: BUB1^F, Bub1^fl
• Gene: Bub1 Location: Chr2:127643036-127673785 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Bub1^tm1Ssta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128455
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7 and a floxed neo cassette was inserted downstream of exon 8. The neo cassette was removed by cre-mediated recombination using a transiently expressing cre vector. (J:128455)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub1 Mutation: 52 strains or lines available

References

• Original: J:128455 Perera D, et al., Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell. 2007 Oct;13(4):566-79
• All: 5 reference(s)