Paxip1^tm2Gdr
Targeted Allele Detail

Summary

• Symbol: Paxip1^tm2Gdr
• Name: PAX interacting (with transcription-activation domain) protein 1; targeted mutation 1, Gregory R Dressler
• MGI ID: MGI:3767658
• Synonyms: ptip^fl, PTIP^flox, ptip^loxP
• Gene: Paxip1 Location: Chr5:27945078-27996689 bp, - strand Genetic Position: Chr5, 13.23 cM, cytoband A3
• Alliance: Paxip1^tm2Gdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128440
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette flanked by FRT sites was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 1. The neo cassette was subsequently removed by flp-mediated recombination. (J:128440, J:148599)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Paxip1 Mutation: 47 strains or lines available

References

• Original: J:128440 Patel SR, et al., The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007 Oct;13(4):580-92
• All: 18 reference(s)