Isl2^{tm3.1(Mnx1-Lhx3)Slp}
Targeted Allele Detail

Summary

• Symbol: Isl2^{tm3.1(Mnx1-Lhx3)Slp}
• Name: insulin related protein 2 (islet 2); targeted mutation 3.1, Samuel L Pfaff
• MGI ID: MGI:3767806
• Synonyms: Lhx3 ki, TgH Isl2^HB9:Lhx3, TgH Lhx3^ON
• Gene: Isl2 Location: Chr9:55445956-55453464 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Isl2^{tm3.1(Mnx1-Lhx3)Slp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63774
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgene containing Lhx3 under the control of the Mnx1 promoter was inserted into the 3' non-coding region. A floxed neo cassette between the promoter and gene being expressed was removed by germline cre-mediated recombination to activate expression. (J:63774)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl2 Mutation: 28 strains or lines available

References

• Original: J:63774 Sharma K, et al., Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature. 2000 Aug 3;406(6795):515-9
• All: 5 reference(s)