Tg(Cd3d-Il5)NJ.1638Nal
Transgene Detail
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Symbol: |
Tg(Cd3d-Il5)NJ.1638Nal |
Name: |
transgene insertion NJ.1638, Nancy A Lee |
MGI ID: |
MGI:3767981 |
Synonyms: |
IL-5tg, NJ.1638 |
Transgene: |
Tg(Cd3d-Il5)NJ.1638Nal Location: unknown
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Alliance: |
Tg(Cd3d-Il5)NJ.1638Nal page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Cd3d-Il5)NJ.1638Nal expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Il5 (MGI:96557) |
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Mutation details: This construct was created by fusing in frame a 170-bp fragment from the 5' end of IL-5 cDNA with the remaining portion of the genomic IL-5 gene. This minigene has no upstream flanking sequences but has all of the introns of the gene as well as 1 .2 kb of downstream flanking sequence. To drive expression of the transgene in T cells, a promoter and tissue-specific enhancer derived from the murine CD3d gene was included upstream. Three founding lines (NJ.759, NJ.1638, NJ.1643) were created with one chosen for further studies. High levels of circulating IL-5 were detected in the sera of transgenic mice but not in wild-type mice.
(J:123440)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:123440 Lee NA, et al., Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J Immunol. 1997 Feb 1;158(3):1332-44 |
All: |
58 reference(s) |
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