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Tg(Cd3d-Il5)NJ.1638Nal
Transgene Detail
Summary
Symbol: Tg(Cd3d-Il5)NJ.1638Nal
Name: transgene insertion NJ.1638, Nancy A Lee
MGI ID: MGI:3767981
Synonyms: IL-5tg, NJ.1638
Transgene: Tg(Cd3d-Il5)NJ.1638Nal  Location: unknown  
Alliance: Tg(Cd3d-Il5)NJ.1638Nal page
Transgene
origin
Strain of Origin:  (CBA/J x C57BL/6J)F1 x C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cd3d-Il5)NJ.1638Nal expresses 1 gene
 
Mutation detailsThis construct was created by fusing in frame a 170-bp fragment from the 5' end of IL-5 cDNA with the remaining portion of the genomic IL-5 gene. This minigene has no upstream flanking sequences but has all of the introns of the gene as well as 1 .2 kb of downstream flanking sequence. To drive expression of the transgene in T cells, a promoter and tissue-specific enhancer derived from the murine CD3d gene was included upstream. Three founding lines (NJ.759, NJ.1638, NJ.1643) were created with one chosen for further studies. High levels of circulating IL-5 were detected in the sera of transgenic mice but not in wild-type mice. (J:123440)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:123440 Lee NA, et al., Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologies. J Immunol. 1997 Feb 1;158(3):1332-44
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory