Chst11^{Gt(PT-1)1Wran}
Gene trapped Allele Detail

Summary

• Symbol: Chst11^{Gt(PT-1)1Wran}
• Name: carbohydrate sulfotransferase 11; gene trap 1, Jeffrey L Wrana
• MGI ID: MGI:3768254
• Synonyms: C4st1^gt
• Gene: Chst11 Location: Chr10:82821332-83031734 bp, + strand Genetic Position: Chr10, 40.66 cM, cytoband C1
• Alliance: Chst11^{Gt(PT-1)1Wran} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128547
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector PT-1 was inserted into intron 1 resulting in a fusion transcript encoding exon1 and lacZ. LacZ expression was monitored by beta-galactosidase assay. Expression analysis confirmed the lack of expression of exons 2 and 3 and reduced protein function was monitored by increasing En2 expression. This allele is likely to be a null allele. (J:128547)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chst11 Mutation: 19 strains or lines available

References

• Original: J:128547 Kluppel M, et al., Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development. 2005 Sep;132(17):3989-4003
• All: 1 reference(s)