Tg(Prnp-MAPT*P301S)PS19Vle
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*P301S)PS19Vle
• Name: transgene insertion PS19, Virginia M Y Lee
• MGI ID: MGI:3768407
• Synonyms: P301S tau (line PS19), PS19 Tg
• Transgene: Tg(Prnp-MAPT*P301S)PS19Vle Location: Chr3:140060041-140309044 bp Genetic Position: Chr3, Syntenic
• Alliance: Tg(Prnp-MAPT*P301S)PS19Vle page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Tg(Prnp-MAPT*P301S)PS19Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The transgene construct contains the P301S mutant human microtubule-associated protein tau, MAPT, under the direction of the mouse prion protein, Prnp, promoter. The expression of the mutant human MAPT is 5-fold higher than the expression of the endogenous mouse Mapt protein. Transgene insertion occurred on Chr 3, causing a 249 Kb deletion. (J:119741)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:119741 Yoshiyama Y, et al., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53(3):337-51
• All: 292 reference(s)