Scn1b^tm2.1Isom
Targeted Allele Detail

Summary

• Symbol: Scn1b^tm2.1Isom
• Name: sodium channel, voltage-gated, type I, beta; targeted mutation 2.1, Lori L Isom
• MGI ID: MGI:3768514
• Synonyms: Scn1b^del
• Gene: Scn1b Location: Chr7:30815949-30826428 bp, - strand Genetic Position: Chr7, 19.3 cM
• Alliance: Scn1b^tm2.1Isom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128713
• Parent Cell Line: Pat5 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Scn1b^tm2Isom mice were mated with transgenic mice that ubiquitously express Cre to remove the floxed allele. Gene inactivation was demonstrated by western blot and by in situ hybridization of brain tissue. (J:128713)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1b Mutation: 8 strains or lines available

References

• Original: J:128713 Chen C, et al., Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b. Genesis. 2007 Sep;45(9):547-53
• All: 1 reference(s)