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Mapttm1(MAPT)Vln
Targeted Allele Detail
Summary
Symbol: Mapttm1(MAPT)Vln
Name: microtubule-associated protein tau; targeted mutation 1, Fred Van Leuven
MGI ID: MGI:3768527
Synonyms: tau-KOKI
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance: Mapttm1(MAPT)Vln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96869
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15. (J:96869)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  430 strains or lines available
References
Original:  J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory