Mapttm1(MAPT)Vln
Targeted Allele Detail
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Symbol: |
Mapttm1(MAPT)Vln |
Name: |
microtubule-associated protein tau; targeted mutation 1, Fred Van Leuven |
MGI ID: |
MGI:3768527 |
Synonyms: |
tau-KOKI |
Gene: |
Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
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Alliance: |
Mapttm1(MAPT)Vln page
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Germline Transmission: |
Earliest citation of germline transmission:
J:96869
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A human MAPT cDNA encoding the longest tau isoform of 441 amino acids containing four repeats, with 2 N-terminal inserts replaced the endogenous mouse gene. Endogenous mouse Mapt protein is not expressed, and the inserted human gene is expressed in brain driven by a murine Thy1 promoter beginning at P15.
(J:96869)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mapt Mutation: |
430 strains or lines available
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Original: |
J:96869 Terwel D, et al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005 Feb 4;280(5):3963-73 |
All: |
2 reference(s) |
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