Stat3^tm1Xyfu
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Xyfu
• Name: signal transducer and activator of transcription 3; targeted mutation 1, Xin-Yuan Fu
• MGI ID: MGI:3768531
• Synonyms: Stat3^flox
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Xyfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86400
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 17 and an additional loxP site was inserted into intron 20. The neo cassette was removed by cre-mediated recombination to leave exons 18, 19 and 20 flanked by loxP sites. (J:86400, J:128719)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:86400 Jacoby JJ, et al., Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12929-34
• All: 94 reference(s)