Chn1^tm1.1Abet
Targeted Allele Detail

Summary

• Symbol: Chn1^tm1.1Abet
• Name: chimerin 1; targeted mutation 1.1, Andrea Betz
• MGI ID: MGI:3768535
• Synonyms: alpha-chimaerin^-
• Gene: Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
• Alliance: Chn1^tm1.1Abet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128724
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed lacZ-IRES cassette with a splice acceptor and a frt-flanked neo cassette were inserted between exon 8 and 9 and an additional loxP site was inserted upstream of exon 8. Cre-mediated recombination was used to remove exon 8 and the lacZ cassette. The absence of alpha1-chimaerin and alpha2-chimaerin was confirmed by western blot analysis on total brain extracts. (J:128724)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chn1 Mutation: 44 strains or lines available

References

• Original: J:128724 Wegmeyer H, et al., EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron. 2007 Sep 6;55(5):756-67
• All: 3 reference(s)