Tg(Tyr-NRAS*Q61K)1Bee
Transgene Detail

Summary

• Symbol: Tg(Tyr-NRAS*Q61K)1Bee
• Name: transgene insertion 1, Friedrich Beemann
• MGI ID: MGI:3768645
• Synonyms: Tyr::N-Ras^Q61K
• Transgene: Tg(Tyr-NRAS*Q61K)1Bee Location: unknown
• Alliance: Tg(Tyr-NRAS*Q61K)1Bee page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr-NRAS*Q61K)1Bee expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NRAS (4893)

  Nras	(MGI:97376)

• Mutation details: The tyrosinase promoter is used to drive the expression of human nras containing the amino acid sustitution lysine for a glutamine at position 61. Expression is directed towards melanocyte lineages. (J:98545)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyr-NRAS*Q61K)1Bee

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:98545 Ackermann J, et al., Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 2005 May 15;65(10):4005-11
• All: 49 reference(s)