Tg(Tyr-DT)3Bee
Transgene Detail

Summary

• Symbol: Tg(Tyr-DT)3Bee
• Name: transgene insertion 3, Friedrich Beemann
• MGI ID: MGI:3768646
• Synonyms: tyr-DTA, Tyr::DT-A, tyr(hs3.6/6.1)-DT-A
• Transgene: Tg(Tyr-DT)3Bee Location: unknown
• Alliance: Tg(Tyr-DT)3Bee page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The tyrosinase promoter is used to drive the expression of diphtheria toxin in melanocytes to achieve ablation of these cells. (J:129095)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129095 Camacho-Hubner A, et al., Increased transgene expression by the mouse tyrosinase enhancer is restricted to neural crest-derived pigment cells. Genesis. 2001 Apr;29(4):180-7
• All: 4 reference(s)