Cd79b^tm3Mnz
Targeted Allele Detail

Summary

• Symbol: Cd79b^tm3Mnz
• Name: CD79B antigen; targeted mutation 3, Michel C Nussenzweig
• MGI ID: MGI:3768659
• Gene: Cd79b Location: Chr11:106202167-106205388 bp, - strand Genetic Position: Chr11, 68.89 cM
• Alliance: Cd79b^tm3Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128768
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The cytoplasmic tail from amino acid position 183 to 228 was replaced with the cytoplasmic tail of Cd79a from amino acid position 161 to 220. A stop codon follows the last amino acid of the inserted Cd79a segment. A floxed neo cassette was inserted downstream of the Ig domain and subsequently removed by cre-mediated recombination. The presence of the modified protein and the absence of the full length endogenous transcript was confirmed by western blot analysis on B cell lysates. (J:128768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd79b Mutation: 36 strains or lines available

References

• Original: J:128768 Reichlin A, et al., A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells. J Exp Med. 2004 Mar 15;199(6):855-65
• All: 1 reference(s)