Frs2^tm1Fwan
Targeted Allele Detail

Summary

• Symbol: Frs2^tm1Fwan
• Name: fibroblast growth factor receptor substrate 2; targeted mutation 1, Fen Wang
• MGI ID: MGI:3768912
• Synonyms: Frs2alpha^flox, Frs2alpha^floxneo
• Gene: Frs2 Location: Chr10:116905332-116984439 bp, - strand Genetic Position: Chr10, 65.09 cM
• Alliance: Frs2^tm1Fwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by loxP sites with one loxP site placed immediately upstream and the other placed 600 bp downstream. A FRT-flanked neo selection cassette was placed between the exon and the downstream loxP site. Mice were crossed with FLP expressing knock-in mice to remove the neo cassette. Insertion of the loxP sites were presumed not to effect gene expression because homozygote mice were born at Mendelian frequencies. (J:128712)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Frs2^tm1Fwan

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frs2 Mutation: 63 strains or lines available

References

• Original: J:128712 Lin Y, et al., Generation of an Frs2alpha conditional null allele. Genesis. 2007 Sep;45(9):554-9
• All: 26 reference(s)