Frs2tm1.1Fwan
Targeted Allele Detail
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Symbol: |
Frs2tm1.1Fwan |
Name: |
fibroblast growth factor receptor substrate 2; targeted mutation 1.1, Fen Wang |
MGI ID: |
MGI:3768913 |
Synonyms: |
Frs2alphanullneo |
Gene: |
Frs2 Location: Chr10:116905332-116984439 bp, - strand Genetic Position: Chr10, 65.09 cM
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Alliance: |
Frs2tm1.1Fwan page
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Germline Transmission: |
Earliest citation of germline transmission:
J:128712
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Frs2tm1Fwan mice were crossed with Cre knockin mice to generate a null allele in the germline. A truncated gene transcript was confirmed by RNAse protection assay on heterozygote kidney extracts. Heterozygotes were indistinguishabe from wild-type mice, suggesting that the truncated transcript did not encode for a dominant-negative protein.
(J:128712)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Frs2 Mutation: |
63 strains or lines available
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Original: |
J:128712 Lin Y, et al., Generation of an Frs2alpha conditional null allele. Genesis. 2007 Sep;45(9):554-9 |
All: |
2 reference(s) |
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