Mlycd^tm1Jish
Targeted Allele Detail

Summary

• Symbol: Mlycd^tm1Jish
• Name: malonyl-CoA decarboxylase; targeted mutation 1, Kou-ichi Jishage
• MGI ID: MGI:3769013
• Synonyms: mcd^-
• Gene: Mlycd Location: Chr8:120121617-120137841 bp, + strand Genetic Position: Chr8, 67.64 cM
• Alliance: Mlycd^tm1Jish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126455
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on extracts from the heart. (J:126455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlycd Mutation: 21 strains or lines available

References

• Original: J:126455 Dyck JR, et al., Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation. 2006 Oct 17;114(16):1721-8
• All: 8 reference(s)