Cigs2^tm1.1Kubo
Targeted Allele Detail

Summary

• Symbol: Cigs2^tm1.1Kubo
• Name: conserved intergenic sequence 2; targeted mutation 1.1, Masato Kubo
• MGI ID: MGI:3769027
• Synonyms: Il4^tm1Kubo
• Gene: Cigs2 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Cigs2^tm1.1Kubo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129048
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region, No functional change, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The HS5 enhancer element in conserved non-coding sequence 2 (CNS-2) was replaced with a loxP site flanked neomycin resistance gene cassette that was subsequently removed by cre-mediated recombination. (J:129048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cigs2 Mutation: 0 strains or lines available

References

• Original: J:129048 Yagi R, et al., Regulation of the Il4 gene is independently controlled by proximal and distal 3' enhancers in mast cells and basophils. Mol Cell Biol. 2007 Dec;27(23):8087-97
• All: 4 reference(s)