Mapk14^tm1Okee
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Okee
• Name: mitogen-activated protein kinase 14; targeted mutation 1, Stephen J OKeefe
• MGI ID: MGI:3769126
• Synonyms: p38alpha(T106M)
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Okee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128965
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A nucleotide substitution of ACG to ATG that results in an amino acid substitution of methionine for threonine at position 106 (T106M) was inserted into exon 4. This mutation does not affect its kinetics. A floxed neo cassette inserted upstream of exon 4 was removed by subsequent cre-mediated recombination. (J:128965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:128965 O'Keefe SJ, et al., Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation. J Biol Chem. 2007 Nov 30;282(48):34663-71
• All: 3 reference(s)