Ptpn3^tm1Rhvh
Targeted Allele Detail

Summary

• Symbol: Ptpn3^tm1Rhvh
• Name: protein tyrosine phosphatase, non-receptor type 3; targeted mutation 1, R Hooft van Huijsduijnen
• MGI ID: MGI:3769232
• Synonyms: PTP-H1^-
• Gene: Ptpn3 Location: Chr4:57190841-57301837 bp, - strand Genetic Position: Chr4, 31.66 cM
• Alliance: Ptpn3^tm1Rhvh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128990
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 15 through 21 were replaced with an in-frame lacZ reporter and neo cassette using Velocigene Technology. Expression of the lacZ cassette was confirmed by immunohistochemistry. Transcript mapping confirmed the loss of the catalytic domain and the production of a modified transcript. (J:128990)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn3 Mutation: 170 strains or lines available

References

• Original: J:128990 Pilecka I, et al., Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth. J Biol Chem. 2007 Nov 30;282(48):35405-15
• All: 1 reference(s)