Ahsp^tm1.1Mjwe
Targeted Allele Detail

Summary

• Symbol: Ahsp^tm1.1Mjwe
• Name: alpha hemoglobin stabilizing protein; targeted mutation 1.1, Mitchell J Weiss
• MGI ID: MGI:3769235
• Synonyms: AHSP-
• Gene: Ahsp Location: Chr7:127902016-127902926 bp, + strand
• Alliance: Ahsp^tm1.1Mjwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77038
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the entire coding region. Mice were then bred to spermadine-cre mice to remove the neo cassette. The resulting offspring have a single loxP site replacing the entire coding region. (J:77038, J:94421)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahsp Mutation: 1 strain or line available

References

• Original: J:77038 Kihm AJ, et al., An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature. 2002 Jun 13;417(6890):758-63
• All: 5 reference(s)