Galnt1^tm1.1Jxm
Targeted Allele Detail

Summary

• Symbol: Galnt1^tm1.1Jxm
• Name: polypeptide N-acetylgalactosaminyltransferase 1; targeted mutation 1.1, Jamey Marth
• MGI ID: MGI:3769258
• Synonyms: ppGalNAcT-1^delta
• Gene: Galnt1 Location: Chr18:24338401-24419873 bp, + strand Genetic Position: Chr18, 12.9 cM, cytoband B1
• Alliance: Galnt1^tm1.1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon three was floxed and subsequently deleted by germ-line cre-mediated recombination. This exon encodes the 5' portion of the GTI motif. Enzymatic activity is absent from the kidney, salivary gland, liver, lung, spleen and thyroid and is reduced in the brain. The authors state that this allele is an enzymatic null allele. (J:128982)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galnt1 Mutation: 138 strains or lines available

References

• Original: J:128982 Tenno M, et al., Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol. 2007 Dec;27(24):8783-96
• All: 4 reference(s)