Pnpla8^tm1Rigr
Targeted Allele Detail

Summary

• Symbol: Pnpla8^tm1Rigr
• Name: patatin-like phospholipase domain containing 8; targeted mutation 1, Richard W Gross
• MGI ID: MGI:3769265
• Synonyms: iPLA2gamma^-
• Gene: Pnpla8 Location: Chr12:44315916-44362718 bp, + strand Genetic Position: Chr12, 20.71 cM
• Alliance: Pnpla8^tm1Rigr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128989
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a neo cassette. This exon is critical to the catalytic domain of the protein product. The absence of the modified transcript was confirmed by northern blot analysis of extracts from the heart, liver, skeletal, and kidney tissue. (J:128989)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla8 Mutation: 39 strains or lines available

References

• Original: J:128989 Mancuso DJ, et al., Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem. 2007 Nov 30;282(48):34611-22
• All: 19 reference(s)