Tfap2a^tm3Will
Targeted Allele Detail

Summary

• Symbol: Tfap2a^tm3Will
• Name: transcription factor AP-2, alpha; targeted mutation 3, Trevor Williams
• MGI ID: MGI:3769332
• Synonyms: Tcfap2a^DCE-
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^tm3Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128903
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: The distal conserved element in intron 5 was replaced with a floxed neo cassette that was subsequently removed by cre-mediated recombination using a transiently expressing vector. Altered expression patterns were determined by whole mount in situ hybridization. (J:128903)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:128903 Feng W, et al., Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme. Mol Cell Biol. 2008 Jan;28(1):315-25
• All: 1 reference(s)