Kat8^tm1Thl
Targeted Allele Detail

Summary

• Symbol: Kat8^tm1Thl
• Name: K(lysine) acetyltransferase 8; targeted mutation 1, Thomas Ludwig
• MGI ID: MGI:3769362
• Synonyms: Kat8^flox, mMof^flox, Mof^flox
• Gene: Kat8 Location: Chr7:127511689-127525010 bp, + strand Genetic Position: Chr7, 69.83 cM
• Alliance: Kat8^tm1Thl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128936
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of intron 1 and an additional loxP site was inserted downstream of exon 3. (J:128936)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat8 Mutation: 38 strains or lines available

References

• Original: J:128936 Gupta A, et al., The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol. 2008 Jan;28(1):397-409
• All: 8 reference(s)