Smad9^tm1Jfm
Targeted Allele Detail

Summary

• Symbol: Smad9^tm1Jfm
• Name: SMAD family member 9; targeted mutation 1, James F Martin
• MGI ID: MGI:3769363
• Synonyms: Smad8^ex4,5
• Gene: Smad9 Location: Chr3:54663003-54708678 bp, + strand Genetic Position: Chr3, 25.62 cM, cytoband D
• Alliance: Smad9^tm1Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128934
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a loxP site and frt flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination deleted exons 4 and 5, which encode most of the MH2 domain, leaving a single loxP site and the frt flanked neo cassette. (J:128934, J:150213)

Tumor Data

List all tumor models in MMHCdb carrying Smad9^tm1Jfm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad9 Mutation: 32 strains or lines available

References

• Original: J:128934 Pangas SA, et al., Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008 Jan;28(1):248-57
• All: 3 reference(s)