Gjb5^tm1Kwi
Targeted Allele Detail

Summary

• Symbol: Gjb5^tm1Kwi
• Name: gap junction protein, beta 5; targeted mutation 1, Klaus Willecke
• MGI ID: MGI:3769388
• Synonyms: Cx31.1^-
• Gene: Gjb5 Location: Chr4:127248600-127251957 bp, - strand Genetic Position: Chr4, 61.51 cM
• Alliance: Gjb5^tm1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128922
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a promoterless lacZ gene with a nuclear localization signal and a floxed PGK-hprt cassette that was subsequently removed by cre-mediated recombination. The absence of transcript was confirmed by northern blot analysis on placenta and skin extracts. (J:128922)

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjb5 Mutation: 19 strains or lines available

References

• Original: J:128922 Zheng-Fischhofer Q, et al., Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol. 2007 Dec 1;312(1):258-71
• All: 3 reference(s)