Zmiz1^tm1Zsu
Targeted Allele Detail

Summary

• Symbol: Zmiz1^tm1Zsu
• Name: zinc finger, MIZ-type containing 1; targeted mutation 1, Zijie Sun
• MGI ID: MGI:3769389
• Synonyms: Zimp10^-
• Gene: Zmiz1 Location: Chr14:25459609-25667167 bp, + strand Genetic Position: Chr14, 15.03 cM
• Alliance: Zmiz1^tm1Zsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128915
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.7 kb fragment including exons 8 - 10 (amino acids 149 - 314) was replaced with a pgk-neo cassette. This deletion resulted in a frameshift producing a missense mutation in the remaining transcript. Western blot analysis of homozygous embryos confirmed the absence of full-length protein. (J:128915)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zmiz1 Mutation: 41 strains or lines available

References

• Original: J:128915 Beliakoff J, et al., The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development. Mol Cell Biol. 2008 Jan;28(1):282-92
• All: 1 reference(s)