Ets2^tm3Rgo
Targeted Allele Detail

Summary

• Symbol: Ets2^tm3Rgo
• Name: E26 avian leukemia oncogene 2, 3' domain; targeted mutation 3, Robert G Oshima
• MGI ID: MGI:3769393
• Synonyms: Ets2^flox, Ets2^tm4Rgo
• Gene: Ets2 Location: Chr16:95503274-95522093 bp, + strand Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
• Alliance: Ets2^tm3Rgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128952
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted into intron 8 and an additional loxP site was inserted into the 3' UTR. The neo cassette was removed by flp-mediated recombination using a transiently expressing vector. (J:128952)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ets2 Mutation: 39 strains or lines available

References

• Original: J:128952 Wen F, et al., Ets2 is required for trophoblast stem cell self-renewal. Dev Biol. 2007 Dec 1;312(1):284-99
• All: 6 reference(s)