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Errfi1tm1.1Jwj
Targeted Allele Detail
Summary
Symbol: Errfi1tm1.1Jwj
Name: ERBB receptor feedback inhibitor 1; targeted mutation 1.1, Jae-Wook Jeong
MGI ID: MGI:3769411
Synonyms: Errfid, Mig-6-
Gene: Errfi1  Location: Chr4:150938376-150953349 bp, + strand  Genetic Position: Chr4, 81.5 cM, cytoband E1
Alliance: Errfi1tm1.1Jwj page
Epidermal hyperplasia in Errfi1tm1.1Jwj/Errfi1tm1.1Jwj mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129106
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe coding alleles 2 through 4 were removed by cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on liver, lung, uterus and skin extracts. (J:129106)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: 129 * C57BL/6 * FVB/N * SJL
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
behavior/neurological
abnormal eating behavior
absent gastric milk in neonates
decreased locomotor activity
cardiovascular system
abnormal lung vasculature morphology
growth/size/body
decreased birth weight
homeostasis/metabolism
cyanosis
integument
epidermal hyperplasia
thick skin
increased skin papilloma incidence
mortality/aging
premature death
postnatal lethality, incomplete penetrance
neoplasm
increased skin papilloma incidence
reproductive system
abnormal uterus morphology
endometrium hyperplasia
increased uterus weight
respiratory system
abnormal lung morphology
abnormal lung vasculature morphology
abnormal lung development
impaired lung alveolus development
abnormal lung interstitium morphology
small lung
overexpanded pulmonary alveolus
pale lung
abnormal respiratory epithelium morphology
bronchiolar epithelial hyperplasia
bronchial epithelial hyperplasia
increased type II pneumocyte number
lung epithelium hyperplasia
skeleton
abnormal joint morphology
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Errfi1 Mutation:  18 strains or lines available
References
Original:  J:129106 Jin N, et al., Generation of a Mig-6 conditional null allele. Genesis. 2007 Nov;45(11):716-21
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory