Trdn^tm1.1Cfp
Targeted Allele Detail

Summary

• Symbol: Trdn^tm1.1Cfp
• Name: triadin; targeted mutation 1.1, Claudio F Perez
• MGI ID: MGI:3769415
• Synonyms: Trdn^-
• Gene: Trdn Location: Chr10:32959479-33352705 bp, + strand Genetic Position: Chr10, 18.37 cM, cytoband B1
• Alliance: Trdn^tm1.1Cfp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo cassette was inserted into the promoter region and an additional loxP site was inserted downstream of exon 1. Exon 1 and neo cassette were removed by germline cre-mediated recombination. The absence of protein product was confirmed by western blot on fast and slow twitch muscle extracts. (J:128951)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trdn Mutation: 59 strains or lines available

References

• Original: J:128951 Shen X, et al., Triadins modulate intracellular Ca2+ homeostasis but are not essential for excitation-contraction coupling in skeletal muscle. J Biol Chem. 2007 Dec 28;282(52):37864-74
• All: 5 reference(s)