Sulf2^{Gt(OST311938)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sulf2^{Gt(OST311938)Lex}
• Name: sulfatase 2; gene trap OST311938, Lexicon Genetics
• MGI ID: MGI:3769472
• Synonyms: Sulf2^{GT(VICTR37)311938Lex}
• Gene: Sulf2 Location: Chr2:165915819-165997603 bp, - strand Genetic Position: Chr2, 86.31 cM, cytoband H3
• Alliance: Sulf2^{Gt(OST311938)Lex} page

Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex} Sulf2^{Gt(OST311938)Lex}/Sulf2^{Gt(OST311938)Lex} embryos display several development defects

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST311938
• Germline Transmission: Earliest citation of germline transmission: J:129305
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTOR37 gene trap vector that contains a promoterless lacZ gene and a neo cassette was inserted into intron 1. Q-RT-PCR confirmed lower expression of the transcript in the testis, liver, spleen and ovary. (J:129305)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sulf2 Mutation: 177 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:129305 Holst CR, et al., Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One. 2007;2(6):e575
• All: 1 reference(s)