Sphk1^tm1Npa
Targeted Allele Detail

Summary

• Symbol: Sphk1^tm1Npa
• Name: sphingosine kinase 1; targeted mutation 1, Novartis Pharma AG
• MGI ID: MGI:3769485
• Synonyms: Sphk1^-
• Gene: Sphk1 Location: Chr11:116421751-116427501 bp, + strand Genetic Position: Chr11, 81.42 cM, cytoband E2
• Alliance: Sphk1^tm1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 3 through 5 were replaced with a neo cassette. (J:129314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk1 Mutation: 29 strains or lines available

References

• Original: J:129314 Zemann B, et al., Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood. 2006 Feb 15;107(4):1454-8
• All: 6 reference(s)