Sphk2^tm1Npa
Targeted Allele Detail

Summary

• Symbol: Sphk2^tm1Npa
• Name: sphingosine kinase 2; targeted mutation 1, Novartis Pharma AG
• MGI ID: MGI:3769486
• Synonyms: SK2^-, Sphk2^-
• Gene: Sphk2 Location: Chr7:45358891-45367426 bp, - strand Genetic Position: Chr7, 29.45 cM
• Alliance: Sphk2^tm1Npa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 6 were replaced with a neo cassette. The lack of transcript expression was confirmed by quantitative real-time PCR on extracts from kidney, liver, and brain. (J:129314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk2 Mutation: 38 strains or lines available

References

• Original: J:129314 Zemann B, et al., Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood. 2006 Feb 15;107(4):1454-8
• All: 9 reference(s)