Tg(AGT)2-5Afu
Transgene Detail

Summary

• Symbol: Tg(AGT)2-5Afu
• Name: transgene insertion 2-5, Akiyoshi Fukamizu
• MGI ID: MGI:3769588
• Synonyms: ANG, hAG2-5, hANG, TgN(hAG)
• Transgene: Tg(AGT)2-5Afu Location: unknown Genetic Position: Chr19, Syntenic
• Alliance: Tg(AGT)2-5Afu page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(AGT)2-5Afu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AGT (183)

  Agt	(MGI:87963)

• Mutation details: A 14-kB genomic fragment containing the entire human angiotensinogen gene and including 1.3Kb of 5' flanking region and 3'flanking region was used to create transgenic mice. Copy number is estimated to be greater than 100. High levels of mRNA encoding human angiotensinogen are found in transgenic mouse liver, and significant levels are detected in kidney and heart. Low levels are detectable in all other tissues examined. In addition to line 2-5, line 3-2 was also created, and has a similar copy number and expression profile. (J:129502)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:129502 Takahashi S, et al., Expression of the human angiotensinogen gene in transgenic mice and transfected cells. Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9
• All: 40 reference(s)