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Tg(Igh-Lmp2a)13FRdni
Transgene Detail
Summary
Symbol: Tg(Igh-Lmp2a)13FRdni
Name: transgene insertion 13F, R D Nicholls
MGI ID: MGI:3769767
Synonyms: EmuLMP2A, TgPWS/AS(del)
Transgene: Tg(Igh-Lmp2a)13FRdni  Location: unknown  
Alliance: Tg(Igh-Lmp2a)13FRdni page
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe Ig heavy chain promoter with Emu enhancer element was used to drive the expression of the Epstein-Barr virus latent membrane protein 2A. Expression was confirmed by RT-PCR of brain extracts. (J:56614)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
9 lines were created with the eight others exhibiting lymphocyte cell lineage defects. Line 13F results in a deletion in chromosome 7 from Mkrn3 to Herc2 (Mkrn3, Ndn, Snurf/Snrpn, Ube3a, and Herc2 are deleted).
References
Original:  J:56614 Gabriel JM, et al., A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9258-63
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory